Mediator subunit Med12 contributes to the maintenance of neural stem cell identity
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چکیده
منابع مشابه
An In Vivo Requirement for the Mediator Subunit Med14 in the Maintenance of Stem Cell Populations
The Mediator complex has recently been shown to be a key player in the maintenance of embryonic and induced pluripotent stem cells. However, the in vivo consequences of loss of many Mediator subunits are unknown. We identified med14 as the gene affected in the zebrafish logelei (log) mutant, which displayed a morphological arrest by 2 days of development. Surprisingly, microarray analysis showe...
متن کاملStem Cell Reports Article An In Vivo Requirement for the Mediator Subunit Med14 in the Maintenance of Stem Cell Populations
Jeffrey T.A. Burrows,1,4 Bret J. Pearson,1,2,4 and Ian C. Scott1,3,4,* 1Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada 2Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada 3Richard Lewar Centre for Excellence in Cardiovascular Research, Toronto, ON M5G 1L7, Canada 4Program in Developmental and Stem Cell Biology, The Hospital for Sick Children...
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T he discovery of neural stem cells (NSCs) in the adult mammalian central nervous system (CNS) has dramatically changed our view on the regenerative capacity of this organ (1, 2). We now realize that the adult brain, including humans, retains the ability to replenish its cellular constituents, neurons and glia, although the extent is very limited compared with lower vertebrates (2). Cell turnov...
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ژورنال
عنوان ژورنال: BMC Developmental Biology
سال: 2016
ISSN: 1471-213X
DOI: 10.1186/s12861-016-0114-0